Effect of High Cholesterol Diet and α-Tocopherol Supplementation on Endoplasmic Retüculum Stress and Apoptosis in Hippocampus Tissue

Objective: Neurodegenerative diseases are life-threatening disorders that occur when cells in peripheral nervous system or brain lose function over time and ultimately die. Our study aimed to establish a high cholesterol fed rabbit model investigate the status of endoplasmic reticulum (ER) stress, proteasome activity apoptosis as well beneficial role α-tocopherol on hippocampus. Methods: Hypercholesterolemic was established by feeding 2% diet for 8 weeks, supplementation applied with intramuscular injections. Alterations Grp78, Grp94, Bax, Bcl-2 BACE1 levels hippocampus tissue were determined western blotting, while measured fluorometric detection. Results: Cholesterol containing weeks increased well-known parameters ER stress apoptosis, together no chance activity. On other hand, rabbits two percent significantly down-regulated certain along an increase Conclusion: results underline novel reducing induced increasing